In recent years, serrapeptase supplements have become popular as an adjunct in pain relief. In places like Japan, the United States, and Europe, they use this treatment to reduce inflammation and pain caused by trauma, conditions, or surgery.
Although it is not considered a first-line approach to disease, some research has made interesting findings about its potential to improve health. Do you want to know more about it? Below we detail its main benefits, some of the side effects, and consumption recommendations.
Contents
What is serrapeptase?
Serrapeptase is a proteolytic enzyme obtained from a bacterium called Serratia E-15 that lives in the digestive tract of the silkworm. Its primary function is to help dissolve the worm’s cocoon once it has transformed into a moth.
However, as a systematic review published in the International Journal of Surgery exposes, it is also notable for its medicinal effects. To be more precise, anti-inflammatory, anti-endemic, and analgesic properties are attributed to it, which can contribute to the relief of various types of ailments.
This enzyme was first isolated in Japan around the 1960s. Soon after, it began to be marketed under “Danzan” and became one of the best-selling dietary supplements in Asia, Europe, and North America.
At present, the evidence on the efficacy and safety of these products remains limited. Due to this, its manufacturer Takeda voluntarily withdrew it from the market in 2011. Even so, other companies continue to produce it and are supported by existing clinical studies.
Potential Benefits of Serrapeptase
Anecdotal data suggests that serrapeptase may contribute to the relief of a wide variety of conditions. However, right now, there is not enough scientific evidence to prove the multiple properties attributed to it.
In any case, there have been small studies that conclude certain benefits. Let’s take a closer look at the most relevant ones.
Oral Health
In research published via the International Journal of Oral and Maxillofacial Surgery, serrapeptase helped decrease pain, jaw muscle spasms, and facial swelling following a tooth extraction procedure. Researchers believe that this enzyme reduces the presence of inflammatory cells in the area involved.
A review of five studies published in this journal found that these supplements are more effective in calming lockjaw (involuntary contraction of the masticatory muscles) after wisdom teeth extraction, compared to ibuprofen and corticosteroids. Still, more evidence is needed.
Pain relief
Another of the most widespread uses of serrapeptase is temporary pain relief. A study revealed by the Journal of International Medical Research observed the effect of this supplement in almost 200 people with inflammatory diseases of the ear, nose, and throat.
After 7-8 days, it was determined that serrapeptase could contribute to a significant reduction in pain. It even seems that it also helps reduce excessive mucus production. Despite this, the investigation is microscopic, with limited conclusions.
infection prevention
One of the more exciting benefits of serrapeptase supplements is the prevention of bacterial infections. Relevant effects have been observed in test-tube and animal studies.
For example, research in the Journal of Hospital Infection suggests that this enzymatic agent increases the efficacy of antibiotics in treating Staphylococcus aureus ( S. aureus ).
Its function is believed to inhibit the formation of biofilms, which act as a barrier against antibiotics to facilitate the growth of bacteria. For this reason, studies show that serrapeptase combined with antibiotics is an excellent strategy to stop the progression of infections, especially in cases of antibiotic-resistant bacteria.
Respiratory diseases
Since its discovery, serrapeptase has been promoted as an adjuvant to reduce sore throat, hoarseness, and sinus congestion. In other words, it is a supplement that improves the symptoms of upper respiratory diseases.
Regarding this, a review published in the Asian Journal of Pharmacological Science determined that this supplement exerts effects similar to drugs that inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-1 (COX-2), which helps to reduce inflammation.
Additionally, it seems to help break down exudates, that is, fluids that leak out of tissues due to inflammation. A small study published in Respirology noted that bronchitis patients receiving serrapeptase had less mucus production than the placebo group.
Other possible benefits
Alternative medicine advocates attributing another wide variety of uses to serrapeptase supplements. But, as the American corporation WebMD points out, the evidence is insufficient. These applications would be the following:
- Back pain.
- Osteoarthritis.
- Rheumatoid arthritis.
- Carpal tunnel syndrome.
- Osteoporosis.
- Headache and migraines.
- Thrombophlebitis.
- Fibromyalgia.
- Fibrocystic disease of the breast.
- Inflammatory bowel disease (IBD).
- Ear infections.
Risks and possible side effects of serrapeptase
For now, there are not enough studies on the adverse reactions of serrapeptase. The long-term effects of its consumption are unknown.
It should be taken in moderation, according to the manufacturer’s instructions. Some studies show that it can cause the following side effects:
- Nausea.
- loss of appetite
- Upset stomach.
- Alterations in blood coagulation.
- Skin reactions.
- Muscle and joint pain.
A report shared in the Journal of Clinical and Diagnostic Research states that serrapeptase can influence the increase in the size of abscesses. For this reason, he suggests avoiding its use in the presence of dental abscesses or of any kind. In these cases, the risk of infections increases.
Its use in children and pregnant or lactating women is not recommended since its effects in these stages are unknown. It should even be used with care in the presence of already-diagnosed diseases.
It should not be taken two weeks before a scheduled surgery due to the risk of bleeding. Nor should it be taken with anticoagulant medications, such as Coumadin ® (warfarin) or Plavix ® (clopidogrel).
Dosage and precautions
At this time, the best way to use serrapeptase is unknown. Doses of up to 30 milligrams daily have been used in clinical trials. Still, supplements are available as capsules, gelcaps, or enteric-coated tablets,, ranging from 34 milligrams to 500 milligrams.
It is recommended to avoid higher doses, as there is no evidence that they work better than lower ones. In case of stomach upset, the ideal is to choose those with enteric coating.
What should you remember about serrapeptase?
Serrapeptase supplements have become famous for their effects on relieving pain and inflammation, especially in oral conditions. However, they are not regulated by the Food and Drug Administration (FDA) and, therefore should be used with care.
If you have previous chronic illnesses or are undergoing medical treatment, it is best to avoid using it until you consult a professional. It should not be ignored that it can cause adverse effects or interactions.